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The biliary system consists of the gallbladder, bile ducts, and three sphincters (ring valves made from smooth muscles used to close body openings). There are two sphincters in the gallbladder and the "Sphincter of Oddi," located where the common bile duct opens into the duodenum. The biliary system is comprised of the organs and ducts by which bile is formed, concentrated, and carried from the liver to the duodenum.

This network of bile-drainage channels carries the bile out of the liver by way of the hepatic ducts, which join together to form a common duct running into the duodenum. Bile gains access into the duodenum by way of the cystic duct. It is first concentrated and then stored until needed in the gallbladder (a pear-shaped reservoir lying in a hollow under the liver).

When food is eaten, fat in the duodenum causes the secretion of digestive hormones, which promote opening of the valves so the bile and pancreatic juices flow into the duodenum. This causes the gallbladder to contract, squeezing stored bile via the cystic and common bile ducts into the duodenum.

The total secretion of bile by the liver cells each day is between 700-1200 ml. The main constituents of bile, apart from waste products, are cholesterol, bile salts, lecithin, and electrolytes. Bile is an extremely important substance, assisting in the digestion and absorption of fats and eliminating waste products from the body.

Bile is also responsible for the following:

• increasing the solubility of cholesterol, fat, and the fat-soluble vitamins A, E, D, and K to aid in their absorption. Fat from food passes from the stomach into the duodenum in the form of large droplets. Bile released into the duodenum contains bile salts that disperse the fat into smaller droplets. The fats now are more easily broken down by the pancreatic enzyme lipase and absorbed through the intestinal lining into the blood.

• keeping the small intestine free from unwanted microorganisms and parasites.

• softening the stool by promoting the incorporation of water into the stool. Without enough bile, the stool can become quite hard and difficult to pass.

• eliminating excess cholesterol.

With age the liver manufactures less and less bile. Stress, chronic infection, inflammation of the pancreas, smoking, drug and alcohol abuse, a sedentary life style, overeating (especially fatty foods), or fasting decreases secretion and elimination of bile.

Liver diseases, such as Hepatitis B & C, Alcoholic Liver Diseases, Fatty Liver, Liver Cirrhosis, parasites, and tumors compromise the function of the biliary system. When the synthesis and secretion of bile is inhibited, toxins stay in the liver longer and cause damaging effects on the liver and general body health.

Gallbladder Stones (Cholelithiasis) and Inflammation (Cholecystitis).

One of the problems of the biliary system is the formation of gallstones, or collections of crystals of cholesterol and/or pigments in the gallbladder or bile ducts. If the liver fails to produce adequate amounts of bile acids, gallstones can form even in people who eat properly.

The chief ingredients of bile are cholesterol and bile acids. Normally, the concentration of bile acids is high enough to keep the cholesterol in liquid form. However, a diet high in animal fats and refined sugars can tip this delicate balance, causing the liver to produce more cholesterol than the bile acids are able to handle. As a result, some of this excess cholesterol begins to solidify into crystals, which we call gallstones.




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